Prostaglandins in human milk
نویسنده
چکیده
Nutritive and antimicrobial aspects of human milk have received considerable attention. However, another, as yet unproved role for breast milk has emerged in recent years: milk may contain factors which modify or supplement physiological functions in the neonate. For example milk lipase1 may assist in neonatal fat digestion, and hormones in milk-such as thyroxine2-may have biologically significant effects. We have been interested in the possibility that milk prostaglandins consumed by the breast-fed infant might influence neonatal physiology-for example, gastrointestinal motility-yet there is very little information about these important lipids in human milk. We have therefore measured in milk, concentrations of prostaglandin E (PG E), prostaglandin F (PG F), together with 13, 14-dihydro-15ketoprostaglandin F (PGFM), thromboxane B2 (TXB2), and 6 ketoprostaglandin Floc (6 keto PGF1a) which are inactive metabolites of PG F, thromboxane A2, and prostacyclin respectively.
منابع مشابه
Linoleic and docosahexaenoic acids in human milk have opposite relationships with cognitive test performance in a sample of 28 countries.
Polyunsaturated fatty acids play critical roles in brain development and function, and their levels in human breast milk closely reflect the long-term diet. The fatty acid contents of human milk samples from 28 countries were used to predict averaged 2009 and 2012 test scores in mathematics, reading, and science from the Program for International Student Assessment. All test scores were positiv...
متن کاملProstaglandins in human milk.
Human milk contains many different components which interact locally in the gastrointestinal tract and stimulate some systemic functions. Among these substances are prostaglandins. We obtained samples of foremilk and hindmilk in 8 lactating women by manual expression before and after 9 a.m. and 9 p.m. on the 3rd day post partum. The following values were found for prostaglandin E2: foremilk, 16...
متن کاملPolyunsaturated fatty acids in maternal plasma and in breast milk.
In order to explain processes underlying the transfer of fatty acids from the maternal compartment into human milk, the lipid content and the fatty acid composition of maternal plasma and milk have been analyzed in breastfeeding mothers at 1 day and 3 months of lactation. The rise in milk lipids occurring during the study period was concomitant with a fall in plasma total fat content, mainly du...
متن کاملUp- and down-regulation of membrane receptors as possible mechanisms related to the antiulcer actions of milk in rat gastric mucosa.
The effects of a cow's milk diet on receptor activity and histamine metabolism in gastric glands and mucosa isolated from adult rats were examined. The milk diet was associated with (1) a decreased mobilization of H2 receptors by histamine and (2) an increased mobilization of PGE2 (prostaglandin E2) receptors in mucous cells (cytoprotective effect) and parietal cells (antiacid effect). These ch...
متن کاملInfluence of dietary source of docosahexaenoic and arachidonic acids on their incorporation into membrane phospholipids of red blood cells in term infants.
Here we studied whether the chemical structure of dietary arachidonic and docosahexaenoic acids in full-term infant diets affects their incorporation into erythrocyte membrane phospholipids. From birth to 3 months, infants were fed breast milk (n = 9) or formula milk containing arachidonic acid and docosahexaenoic acid provided by egg phospholipids (n = 10) or by low-eicosapentaenoic acid fish ...
متن کامل